منابع مشابه
The Functions of Metamorphic Metallothioneins in Zinc and Copper Metabolism
Recent discoveries in zinc biology provide a new platform for discussing the primary physiological functions of mammalian metallothioneins (MTs) and their exquisite zinc-dependent regulation. It is now understood that the control of cellular zinc homeostasis includes buffering of Zn2+ ions at picomolar concentrations, extensive subcellular re-distribution of Zn2+, the loading of exocytotic vesi...
متن کاملSpectroscopic Studies of Copper, Silver and Gold-Metallothioneins
Metallothionein is a ubiquitous protein with a wide range of proposed physiological roles, including the transport, storage and detoxification of essential and nonessential trace metals. The amino acid sequence of isoform 2a of rabbit liver metallothionein, the isoform used in our spectroscopic studies, includes 20 cysteinyl groups out of 62 amino acids. Metallothioneins in general represent an...
متن کاملSpectroscopic Studies of Copper and Silver Binding to Metallothioneins
MAMMALIAN METALLOTHIONEIN IS REMARKABLE IN ITS METAL BINDING PROPERTIES: well-characterized species exist for metal to sulfur ratios of M(7)S(20), M(12)S(20), and M(18)S(20), where M = Cd(ll), Zn(ll), Hg(ll), Ag(I), Au(I), and Cu(I). Circular dichroism and luminescence spectra provide rich details of a complicated metal binding chemistry when metals are added directly to the metal free- or zinc...
متن کاملCadmium and copper metallothioneins in the American lobster, Homarus americanus.
Lobsters were fed cadmium-rich oysters for 28 days, and the induction of cadmium metallothionein and its relation to concentrations of cadmium, copper, and zinc in the digestive gland and gills was determined. A portion of the tissues also was retained for determining the cytosolic distribution of these metals by gel filtration and ion-exchange chromatography. The digestive gland contained a ma...
متن کاملExamining the specific contributions of individual Arabidopsis metallothioneins to copper distribution and metal tolerance.
Metallothioneins (MTs) are small cysteine-rich proteins found in various eukaryotes. Plant MTs are classified into four types based on the arrangement of cysteine residues. To determine whether all four types of plant MTs function as metal chelators, six Arabidopsis (Arabidopsis thaliana) MTs (MT1a, MT2a, MT2b, MT3, MT4a, and MT4b) were expressed in the copper (Cu)- and zinc (Zn)-sensitive yeas...
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ژورنال
عنوان ژورنال: IUBMB Life
سال: 2017
ISSN: 1521-6543
DOI: 10.1002/iub.1618